Is There a Predictable Cost-Benefit Ratio in Preeclampsia?

Area of Science:

• Obstetrics and Gynecology
• Perinatal Medicine
• Inflammatory Markers in Pregnancy

Background:

• Preeclampsia (PE) affects 2-8% of pregnancies and is linked to systemic inflammatory response (SIR) markers.
• Identifying predictive markers for PE is crucial for high-risk pregnancies.

Purpose of the Study:

• To investigate the predictive role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-platelet ratio index (APRI) in preeclampsia.
• To determine the clinical significance of these SIR markers in predicting PE development.

Main Methods:

• A cohort of 300 pregnant women (151 with PE, 149 controls) was studied.
• Blood samples were analyzed for NLR, PLR, and APRI at hospitalization.
• Receiver operating characteristic (ROC) curve analysis was used to assess predictive capabilities.

Main Results:

• No significant differences were observed in mean NLR, PLR, and APRI values between the PE and control groups.
• ROC analysis indicated that none of these parameters could reliably predict preeclampsia.
• Hypertensive individuals were hospitalized earlier, with significantly higher blood pressure.

Conclusions:

• Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and APRI do not possess clinical significance for predicting preeclampsia.
• These inflammatory markers are not useful in assessing the developmental risk of PE.