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Angiotensin II Type 1 Receptor Antibody-Mediated Kidney Rejection Unresponsive to Treatment
David Allison1, Zahraa Hajjiri2, Luis Manon1
1Pathology, University of Illinois at Chicago, Chicago, USA.
Abstract:
Allograft rejection is a significant cause of renal transplant failure which needs prompt diagnosis and treatment for graft salvage. Angiotensin II type 1 receptor antibody-mediated rejection (AT1R-AMR) is increasingly being identified as the etiology of antibody-mediated rejection in kidney transplant recipients with allograft rejection but without detectable human leukocyte antigen (HLA) antibodies. While some reports have suggested that AT1R-AMR may be refractory to standard therapy, others have reported improvement or stabilization of graft function. We present two patients in which anti-rejection therapy including therapeutic plasma exchange was unable to salvage the allograft.
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