Variabilities in apparent diffusion coefficient (ADC) measurements of the spleen and the paraspinal muscle: A single...

Evaluation of the variabilities in apparent diffusion coefficient (ADC) measurements of the spleen (ADC_spleen) and the paraspinal muscles (ADC_muscle) to identify the reference organ for normalizing the ADC from the abdominal diffusion weighted imaging (DWI).

Two MRI scanners, with 314 abdominal exams on the GE and 929 on the Siemens system, were used for MRI examinations including DWI (b-values, 50 and 800 s/mm²). For a subset of 73 exams on the Siemens system a second exam was conducted. Four regions of interest (ROIs) in each exam were placed to measure the ADC_spleen and the bilateral ADC_muscle. ADC variability between patients (on each scanner separately), ADC variability due to ROI placement between the two ROIs in each organ, and variability in the subset between the first and second exams were assessed.

The ADC_spleen was more scattered and variable than the ADC_muscle in the comparability (n = 929 and 314 for two MRI scanners, respectively) and repeatability (n = 73) datasets. The Bland-Altmann bias and limits of agreement (LoAs) for the ADC_spleen (ICC, 0.47; CV, 0.070) and ADC_muscle (ICC, 0.67; CV, 0.023) in the repeatability datasets (n = 73) were -0.1 (-25.7%-25.6%) and -0.3 (-8.8%-8.1%), respectively. For the Siemens system, the Bland-Altmann bias and LoAs for the ADC_spleen (ICC, 0.72; CV, 0.061) and ADC_muscle (ICC, 0.53; CV, 0.030) in the comparability datasets (n = 929) were 2.1 (-20.0%-24.2%) and 0.7 (-10.0%-11.4%), respectively. Similar findings have been found in the GE system (n = 314). The CVs for the ADC_muscle measurements were lower than those of the ADC_spleen both in the repeatability and the comparability analyses (all p < 0.001).

Paraspinal muscles demonstrate better reference characteristics than the spleen in estimating ADC variability of abdominal DWI.