Peri-implantitis and systemic inflammation: A critical update

Area of Science:

• Oral Health
• Inflammatory Diseases
• Biomarkers

Background:

• Peri-implantitis is an inflammatory condition affecting tissues around dental implants, potentially compromising treatment success.
• Emerging evidence suggests links between peri-implant health and systemic inflammation (e.g., diabetes, cardiovascular disease, COVID-19).
• The relationship between peri-implant disease and systemic inflammation is not well understood, unlike that of periodontal disease.

Purpose of the Study:

• To comprehensively review current evidence on the association between peri-implantitis and systemic inflammation.
• To focus on the biological mechanisms, microbiology, and key biomarkers involved in this relationship.
• To enhance understanding and stimulate further research into peri-implantitis and its systemic implications.

Main Methods:

• Systematic literature review of recent studies.
• Analysis of biological complications, microbiological findings, and identified biomarkers.
• Synthesis of evidence linking peri-implantitis to systemic inflammatory pathways.

Main Results:

• Peri-implantitis can elevate circulating pro-inflammatory cytokines, potentially impacting overall health.
• Specific biomarkers may indicate a link between peri-implant inflammation and systemic conditions.
• The exact nature and extent of systemic impact require further investigation.

Conclusions:

• Peri-implantitis represents a potential source of systemic inflammation with implications for overall health.
• Further research is crucial to elucidate the complex interplay between peri-implantitis and systemic inflammatory diseases.
• Understanding these links can lead to improved patient management and treatment outcomes.