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Case report: Intensive statin and PCSK-9 inhibitor combo reduces plaque volume and stenosis in ischemic stroke

Weiqi Zeng1, Yunfei Shi2, Meng Fan3

  • 1Department of Neurology, The First People's Hospital of Foshan, Foshan, Guangdong, China.

Heliyon
|July 31, 2023
PubMed

Insights

Intracranial atherosclerotic ischemic stroke can be alleviated by combining PCSK9 inhibitors with statin therapy. This combination may reverse plaque buildup in intracranial arteries, improving outcomes for elderly patients.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Intracranial atherosclerotic ischemic stroke significantly affects elderly quality of life.
  • Statins are effective for plaque stabilization in this condition, potentially due to lipid level effects.
  • Anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel lipid-lowering drugs for high cardiovascular risk patients.

Keywords:
HR-MRIIntensive statinPCSK-9 inhibitorSymptomatic intracranial artery stenosisTCD

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