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Updated: Aug 1, 2026
12:40
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
Transfusion-related sepsis after prolonged platelet storage
The American Journal of Medicine
|September 1, 1986
Summary
Bacterial contamination in blood platelets can occur from scarred donor sites. Extended room-temperature storage of platelets increases the risk of serious infections in recipients.
Area of Science:
- Microbiology
- Transfusion Medicine
- Infectious Disease
Background:
- Standard iodophor preparation may not eliminate bacteria from scarred venipuncture sites in frequent blood donors.
- Prolonged room-temperature storage of platelets can allow bacterial proliferation.
Observation:
- Scarred (dimpled) antecubital fossa sites can harbor bacteria resistant to standard sterilization.
- Three episodes of platelet contamination and four cases of sepsis were linked to a single donor's "dimpled" site.
Findings:
- Platelets from the affected donor, stored >80 hours at 22°C, led to contamination and sepsis.
- Platelets from the same donor, stored ≤50 hours at 22°C, showed no complications in 25 patients.
Implications:
- Extended platelet storage at 22°C necessitates vigilance against extrinsic bacterial contamination.
- Gram-positive bacteria can proliferate during prolonged storage, posing infectious risks to transfusion recipients.
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