Antibacterial properties of sodium nalidixate against avian Salmonellae in liquid and on solid media

The in vitro inhibitory effect of sodium nalidixate (NaNA) for 206 avian salmonella cultures of varying serotypes was established in both liquid and on solid media. Salmonella cultures were much more resistant to the lethal effects of NaNA in veal infusion broth than on a solid medium such as MacConkey agar. The inhibitory effects of NaNA varied in liquid media, depending on the nutritive support afforded by the medium. Growth-suppressive effects were enhanced by less nutritive media. Reasons are suggested as to the possible differences in the inhibitory effect of NaNA on avian salmonella cultures grown in liquid and on solid media.