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Published on: March 4, 2014
Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria
Brahman Shankar Sivakumar1, Vincent Vin Gia An2, Nicholas Stewart3
1Department of Hand Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Abstract:
Alkaptonuria is a rare metabolic disorder characterized by the accumulation of homogentisic acid. Its effects on the central nervous system are well-recognized; however, cases of pathologic homogentisic acid deposition in the peripheral nervous system are less well-described. We report the case of a 72-year-old man with a prior history of alkaptonuria presenting with bilateral carpal tunnel and left-sided cubital tunnel symptoms. This case is of note because the patient demonstrated a rapid onset of symptoms due to pathology at multiple foci.
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