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Clinical features of 162 fatal cases of COVID-19: a multi-center retrospective study

Xianlong Zhou1, Guoyong Ding2, Qing Fang3

  • 1Emergency Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Emergency and Critical Care Medicine
|July 31, 2023
PubMed

Insights

Fatal COVID-19 cases predominantly affected older males, often with hypertension. However, even younger patients without comorbidities could experience severe outcomes, highlighting the unpredictable nature of the disease.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Limited data existed on fatal cases of coronavirus disease 2019 (COVID-19), despite its global impact.
  • Understanding the characteristics of fatal COVID-19 cases is crucial for public health strategies.

Purpose of the Study:

  • To describe the clinical features of 162 fatal coronavirus disease 2019 (COVID-19) cases.
  • To analyze demographic data, symptoms, comorbidities, and treatment outcomes in deceased COVID-19 patients.

Main Methods:

  • Retrospective review of electronic medical records for 162 fatal COVID-19 cases.
  • Data collected included demographics, clinical presentation, comorbidities, laboratory results, CT scans, treatments, and complications.

Main Results:

  • The median age of deceased patients was 69.5 years, with 80% over 61. Men comprised 69.1% of fatalities.
  • Hypertension was the most common comorbidity (45.1%), though 36.4% had no prior conditions.
  • Most patients presented with severe or critical COVID-19, with 93.2% developing respiratory failure or ARDS. Mechanical ventilation was common, often preceding ICU admission.

Conclusions:

  • Fatal outcomes can occur in younger COVID-19 patients without comorbidities.
  • In-hospital survival times for fatal cases were consistent across different hospital levels in Wuhan.
Abstract

Keywords:
Clinical featuresCoronavirus disease 2019Fatal casesSurvival time

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