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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...

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Related Experiment Video

Updated: Jul 20, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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Published on: July 20, 2022

Research progress of non-coding RNA in atrial fibrillation.

Zongqian Xue¹, Jinbiao Zhu¹, Juan Liu¹

¹Department of Cardiology, Aoyang Hospital Affiliated to Jiangsu University, Zhangjiagang, China.

Frontiers in Cardiovascular Medicine

|July 31, 2023

Summary

Atrial fibrillation (AF) is a growing health concern, especially with an aging population. Research into non-coding RNAs (ncRNAs) may offer new diagnostic markers and targeted therapies for this common heart rhythm disorder.

Keywords:

atrial fibrillation biomarker diagnosis exosome ncRNAs

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Area of Science:

Cardiology
Molecular Biology
Genetics

Background:

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with increasing incidence, particularly in aging populations.
AF significantly impacts patient quality of life and can lead to severe complications like thrombosis and heart failure.
Current diagnostic and therapeutic strategies for AF lack specific serum markers and targeted treatments.

Purpose of the Study:

To explore the role of non-coding RNAs (ncRNAs) in the pathophysiology of atrial fibrillation.
To identify potential ncRNA biomarkers for AF diagnosis.
To investigate ncRNAs as targets for novel AF therapies.

Main Methods:

Review of current literature on ncRNAs in cardiovascular diseases.
Analysis of studies investigating ncRNA involvement in AF development and progression.
Exploration of ncRNAs in other cardiovascular conditions like myocardial infarction and atherosclerosis.

Main Results:

ncRNAs are implicated in the occurrence and development of AF.
ncRNAs play roles in the pathophysiological processes of myocardial infarction and atherosclerosis.
ncRNAs show potential as biomarkers for cardiovascular diseases, including AF.

Conclusions:

Understanding the pathophysiological mechanisms of AF involving ncRNAs is crucial.
ncRNAs represent promising targets for the development of specific diagnostic markers and targeted therapies for AF.
Further research into ncRNAs can lead to a more systematic diagnostic and treatment framework for atrial fibrillation.