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Serum CDC42 reflects the exacerbation risk and severity, Th1/2 cell imbalance and inflammation in asthmatic children

Ning Yang1, Jielin Gao2, Yanjun Han1

  • 1Department of Pediatrics, Infection & Digestion, Xingtai People's Hospital, Xingtai, Hebei, 054031, China.

Biomarkers in Medicine
|July 31, 2023
PubMed

Insights

Serum CDC42 levels are elevated in children with asthma, particularly during exacerbations. Higher CDC42 indicates increased asthma severity, inflammation, and a skewed Th1/Th2 immune response.

Area of Science:

  • Immunology
  • Pediatric Pulmonology
  • Molecular Biology

Background:

  • Asthma is a chronic respiratory disease characterized by airway inflammation and immune dysregulation.
  • Cell division control protein 42 (CDC42) is involved in cellular signaling pathways relevant to immune responses.
  • Understanding biomarkers for asthma exacerbations and immune status in children is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical significance of serum CDC42 levels in pediatric asthma.
  • To correlate CDC42 concentrations with asthma exacerbation status, severity, and immune profiles in children.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum CDC42 levels.
  • Study included 80 asthmatic children during exacerbation, 80 in remission, and 40 healthy controls.
  • Correlations were analyzed between CDC42 levels and clinical parameters, including exacerbation severity and Th1/Th2 cytokine profiles.

Main Results:

  • Serum CDC42 levels were significantly higher in asthmatic children experiencing exacerbation, followed by those in remission, and healthy controls (p < 0.001).
  • In exacerbating asthmatic children, CDC42 positively correlated with exacerbation severity, Th2, TNF-α, IL-6, and IL-8, and negatively with the Th1/Th2 ratio.
  • In children with asthma in remission, CDC42 correlated with a lower Th1/Th2 ratio and higher TNF-α.

Conclusions:

  • Circulating CDC42 serves as a potential biomarker reflecting exacerbation risk in pediatric asthma.
  • Serum CDC42 levels are associated with Th1/Th2 immune imbalance and systemic inflammation in asthmatic children.
  • CDC42 may play a role in the pathogenesis or reflect the inflammatory state of childhood asthma.

Keywords:
CDC42T-helper cellsasthmatic childrenexacerbation severityinflammatory cytokines

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