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Azvudine therapy of common COVID-19 in hemodialysis patients

Shunlai Shang1,2, Bo Fu2, Yanqiu Geng3

  • 1Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.

Journal of Medical Virology
|July 31, 2023
PubMed

Insights

Azvudine (FNC) antiviral therapy improved COVID-19 outcomes in hemodialysis patients. This study found FNC significantly increased negative nucleic acid conversion rates and reduced viral loads compared to basic treatment.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Antiviral Therapy

Background:

  • Hemodialysis patients are vulnerable to COVID-19 complications.
  • Limited research exists on antiviral treatments for COVID-19 in this population.
  • The efficacy of 2'-deoxy-2'-β -fluoro-4'-azidocytidine (Azvudine, FNC) in hemodialysis patients with COVID-19 is unexplored.

Purpose of the Study:

  • To evaluate the safety and effectiveness of Azvudine (FNC) in hemodialysis patients with COVID-19.
  • To compare FNC treatment with standard care for COVID-19 in this patient group.

Main Methods:

  • A multicenter observational study included 1008 hemodialysis patients with COVID-19.
  • Matched analysis compared 182 patients receiving FNC with 182 patients receiving basic treatment.
  • Outcomes assessed included nucleic acid conversion, viral load, inflammatory markers, and adverse events.

Main Results:

  • The FNC group showed a significantly higher negative nucleic acid conversion rate (p < 0.05).
  • Viral loads, interleukin-6, and C-reactive protein levels were significantly lower in the FNC group (p < 0.05).
  • No significant differences were observed in liver function, renal function, or adverse events between groups (p > 0.05).

Conclusions:

  • Azvudine (FNC) demonstrated potential as a safe and effective antiviral therapy for COVID-19 in hemodialysis patients.
  • FNC offers a promising treatment option, improving virological and inflammatory outcomes without compromising safety in this vulnerable population.

Keywords:
AzvudineCOVID-19SARS-CoV-2adverse eventsefficacyhemodialysis

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