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Glomerular capillary permeability in developing canines.

D I Goldsmith, R A Jodorkovsky, J Sherwinter

    The American Journal of Physiology
    |September 1, 1986
    PubMed
    Summary
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    Glomerular filtration rate increases with age due to a larger pore area, not changes in pore size. This study in puppies shows developmental changes in kidney filtration capacity.

    Area of Science:

    • Nephrology
    • Developmental Biology
    • Physiology

    Background:

    • Glomerular permeability changes during development, impacting kidney function.
    • Understanding these developmental changes is crucial for pediatric nephrology.

    Purpose of the Study:

    • To assess developmental changes in glomerular permeability in canine puppies.
    • To determine the factors influencing the rise in glomerular filtration rate during development.

    Main Methods:

    • Dextran-sieving curves were analyzed in 1- and 6-week-old canines.
    • Mathematical modeling of glomerular capillaries, incorporating axial protein concentration changes.
    • Analysis using classical pore theory.

    Main Results:

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    • Glomerular pore radius remained constant (approx. 62 A) between 1 and 6 weeks of age.
    • Total cross-sectional pore area (Aw/delta x) increased approximately 7.5-fold.
    • The ultrafiltration coefficient rose significantly with age.

    Conclusions:

    • Glomerular pore size is constant during early development in canines.
    • The increase in glomerular filtration rate is primarily driven by a larger total pore area.
    • This expansion in pore area results from increased surface area and pore density in glomerular capillaries.