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Prevalence of baseline hypocalcemia and symptomatic hypocalcemia during leukapheresis

Kimberly Bray1, Carolyn Lynde1, Trizzie Vu1

  • 1Apheresis Clinic, Valrico, Florida, USA.

Journal of Clinical Apheresis
|July 31, 2023
PubMed

Insights

Hypocalcemia symptoms affect up to 50% of patients during leukapheresis. Older age, higher albumin, and longer procedures increase the risk of symptomatic hypocalcemia during this process.

Area of Science:

  • Hematology
  • Nephrology
  • Critical Care Medicine

Background:

  • Hypocalcemia symptoms occur in up to 50% of patients undergoing leukapheresis.
  • Current practices for calcium supplementation during leukapheresis lack standardization.
  • Acid citrate dextrose solution A is commonly used in leukapheresis.

Purpose of the Study:

  • To determine the prevalence of baseline and symptomatic hypocalcemia during leukapheresis using acid citrate dextrose solution A.
  • To identify patient characteristics associated with symptomatic hypocalcemia during leukapheresis.

Main Methods:

  • Retrospective, descriptive study design.
  • Analysis of patient data from leukapheresis procedures.
  • Statistical identification of factors correlated with symptomatic hypocalcemia.

Main Results:

  • 3% of patients had pre-existing hypocalcemia.
  • 35% of patients experienced symptomatic hypocalcemia during leukapheresis.
  • Increased risk of symptomatic hypocalcemia was associated with older age, higher albumin levels, and longer procedure duration.

Conclusions:

  • Symptomatic hypocalcemia is a common complication during leukapheresis.
  • Patient age, albumin levels, and procedure length are key risk factors for symptomatic hypocalcemia.
  • Further research is needed to establish standardized calcium supplementation protocols.

Keywords:
acid citrate dextrose solution A (ACD-A)apheresisapheresis side effectsoncologyserum calciumserum ionized calciumsymptom management

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