Eight Strategies to Engineer Acceptance of Human Germline Modifications.

Area of Science:

• Bioethics
• Genetics
• Public Policy

Background:

• Scientific consensus previously opposed pregnancy with genetically manipulated embryos, including via Mitochondrial Replacement Therapy (MRT) and human germline genome editing (HGGE).
• Most countries legally prohibit or restrict heritable human germline modifications.
• Recent years show a shift with calls for regulatory pathways and emphasis on public engagement.

Purpose of the Study:

• To identify and describe strategies used by proponents to influence public perception and policy regarding human germline modifications.
• To highlight how certain narratives may undermine honest public and scientific engagement.

Main Methods:

• Analysis of discourse and strategies employed by proponents of human germline modifications.
• Identification of eight discrete manipulative tactics used in public and policy discussions.

Main Results:

• Proponents utilize specific framing and narrative strategies to sway public opinion and influence policymaking.
• These strategies aim to incrementally shift consensus towards acceptance of heritable human germline modifications.
• The identified tactics can hinder transparent and informed public discourse.

Conclusions:

• Awareness of these manipulative strategies is crucial for genuine public engagement and ethical governance of HGGE.
• Oversight is needed to ensure that advocacy for genetic technologies does not rely on distorted information.
• Promoting critical evaluation of narratives surrounding human germline modification is essential for responsible scientific advancement.