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Clinicopathologic features and long-term prognosis of hepatitis B virus-associated glomerulonephritis: a

Hailing Lu1, Yu Li2, Maxiu Lai1

  • 1Department of Nephrology, 900 Hospital of the Joint Logistics Team, PLA, Fuzhou General Clinical Medical College of Fujian Medical University, 156 Xierhuanbei Road, Fuzhou, 350025, Fujian, China.

Journal of Nephrology
|July 31, 2023
PubMed

Insights

Hepatitis B virus-associated glomerulonephritis (HBV-GN) is a serious kidney disease. Hypertension, hyperuricemia, and specific kidney lesions predict poor outcomes, but antiviral therapy may improve prognosis.

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Hepatitis B virus-associated glomerulonephritis (HBV-GN) is a common secondary glomerulonephritis in China.
  • The clinicopathological features and long-term prognosis of HBV-GN are not fully understood.

Purpose of the Study:

  • To explore the clinicopathological features and long-term prognosis of HBV-GN.
  • To identify predictors of long-term outcomes in HBV-GN patients.

Main Methods:

  • Retrospective analysis of 259 biopsy-proven HBV-GN patients from November 1994 to December 2013.
  • Composite endpoints included doubling serum creatinine, end-stage renal disease, or renal death.
  • Clinicopathological features and Cox regression analysis were used to identify prognostic predictors.

Main Results:

  • The median age was 31 years, with 71% males. Common patterns included IgA nephropathy and membranous nephropathy.
  • Hypertension, hyperuricemia, glomerulosclerosis, and intrarenal arterial lesions were independent predictors of adverse outcomes.
  • Patients receiving antiviral therapy showed a significantly better prognosis than those who did not.

Conclusions:

  • HBV-GN has distinct clinicopathological features and is not a benign condition in adults.
  • Hypertension, hyperuricemia, glomerulosclerosis, and intrarenal arterial lesions are key prognostic predictors.
  • Antiviral therapy can improve the long-term prognosis of HBV-GN patients.
Abstract

Keywords:
Hepatitis B virus-associated glomerulonephritisMembranous nephropathyPredictorPrognosis

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