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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Pancreatitis I: Introduction01:27

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Pediatric Autoimmune Pancreatitis: A Single-Center Retrospective Case Series.

Erica C Becker1, Rakesh Kumar2, Adnan Altaf2

  • 1From the Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT.

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Summary

Autoimmune pancreatitis (AIP) is rare in children, presenting with pain and jaundice. Steroid treatment showed prompt symptom resolution, indicating a good prognosis for this pediatric condition.

Keywords:
autoimmune pancreatitisimmunoglobulin G4lymphoplasmacytic infiltrationpancreatic fibrosis and atrophy

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Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Hepatology

Background:

  • Autoimmune pancreatitis (AIP) is a rare immune-mediated pancreatic condition.
  • Limited data exists on pediatric AIP presentation and outcomes.

Purpose of the Study:

  • To describe the presentation, symptoms, and outcomes of pediatric AIP.
  • To enhance understanding of this rare condition in children.

Main Methods:

  • Single-center case series of 4 pediatric patients.
  • Diagnosis based on serology, imaging, histology, and steroid response.
  • Data included demographics, symptoms, imaging, organ involvement, histology, treatment, and outcomes.

Main Results:

  • All patients had type 2 AIP with abdominal pain, emesis, and jaundice.
  • Imaging revealed pancreatic enlargement and bile duct strictures.
  • Biopsies showed lymphoplasmacytic infiltration and fibrosis.
  • Prednisone treatment led to symptom and lab normalization.

Conclusions:

  • Pediatric AIP is rare with distinct clinical, radiographic, and histological features.
  • Type 2 AIP in children shows a good long-term prognosis.
  • Prompt response to steroid therapy observed.