Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

371
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
371
Respiratory Volumes and Capacities I01:26

Respiratory Volumes and Capacities I

1.1K
Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
1.1K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K
Respiratory Volumes and Capacities01:22

Respiratory Volumes and Capacities

2.2K
The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
2.2K
Lung Capacity01:47

Lung Capacity

50.7K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
50.7K
Respiratory Volumes01:15

Respiratory Volumes

1.5K
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is acute respiratory distress syndrome a preventable disease?

Intensive care medicine·2026
Same author

Estimating a Physiological Lung Function Score and Biological Sex Using Pulmonary Function Tests and Machine Learning: Retrospective Study.

JMIR AI·2026
Same author

The Association of Microplastics in Peripheral Blood and Pulmonary Disease: A Pilot Study.

Journal of xenobiotics·2026
Same author

Unravelling the Links Between Gastroesophageal Reflux and Lung Disease: New Insights.

Digestive diseases and sciences·2026
Same author

Clinical Characteristics and Outcomes of Pneumocystis Pneumonia in Solid Organ Transplant Recipients.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

The Utility and Safety of Repeat Talc Administration for Pleurodesis after Immediate and Delayed Pleurodesis Failure.

Respiration; international review of thoracic diseases·2025

Related Experiment Video

Updated: Jul 20, 2025

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

750

Application of Global Lung Function Initiative Global Spirometry Reference Equations across a Large, Multicenter

Amjad N Kanj1, Paul D Scanlon1, Hemang Yadav1

  • 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.

American Journal of Respiratory and Critical Care Medicine
|July 31, 2023
PubMed
Summary

The new Global Lung Function Initiative (GLI) Global spirometry equations significantly alter lung function interpretations, especially for Black individuals, impacting diagnosis across diverse populations.

Keywords:
GLI Globalethnicityhealth disparitiesracial groupsspirometry

More Related Videos

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.4K
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.6K

Related Experiment Videos

Last Updated: Jul 20, 2025

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

750
Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.4K
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.6K

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Clinical Diagnostics

Background:

  • The Global Lung Function Initiative (GLI) developed new
  • race-neutral
  • spirometry reference equations (GLI Global) to replace race-specific ones (GLI-2012).

Purpose of the Study:

  • To assess the impact of using GLI Global equations versus GLI-2012 on predicted lung function measurements.
  • To quantify changes in spirometry interpretation across diverse racial and ethnic groups.

Main Methods:

  • A multicenter, cross-sectional study reanalyzed 109,447 spirometry tests.
  • Data were stratified by self-reported race and ethnicity to compare GLI Global with GLI-2012 standards.

Main Results:

  • Mean FEV1 and FVC percent predicted changed differently across racial groups, increasing in White and Northeast Asian, decreasing in Black and Southeast Asian groups.
  • Obstruction prevalence increased in White individuals (9.7%), while restriction prevalence rose in Black (51.1%) and Southeast Asian (37.1%) groups.
  • GLI Global altered spirometry interpretation for 10.2% of tests; Black individuals showed a 32.9% relative increase in abnormal results.

Conclusions:

  • The GLI Global equations significantly impact spirometry interpretation, necessitating careful clinical contextualization.
  • While offering a move away from race-specific equations, the clinical implications require further understanding.