Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

1.4K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.4K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

3.7K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
3.7K
Ankle Joint01:10

Ankle Joint

1.6K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
1.6K
Knee Joint01:23

Knee Joint

1.9K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
1.9K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

2.3K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
2.3K
Glycosaminoglycans01:23

Glycosaminoglycans

4.9K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is a Resorbable Citrate-based Bioceramic Device Associated With Osseous Integration? An Early Retrospective MRI Analysis.

Clinical orthopaedics and related research·2026
Same author

Outcomes Following Conversion of Ankle Fusion to Transfibular Total Ankle Arthroplasty.

Foot & ankle orthopaedics·2026
Same author

A qualitative study to inform a parental education intervention for unintentional child injury prevention in rural Nepal.

Frontiers in public health·2026
Same author

Immortalization and Targeted Enrichment of HIV-Infected CD4<sup>+</sup> T-Cells from Patients Under Antiretroviral Therapy.

International journal of molecular sciences·2026
Same author

Outcomes of iliac crest bone marrow aspirate injection in the treatment of recalcitrant plantar fasciitis.

International orthopaedics·2026
Same author

Synovial histopathology in common orthopaedic joint conditions assessed with a modified Krenn synovitis score.

Histology and histopathology·2025

Related Experiment Video

Updated: Jul 20, 2025

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

20.8K

Mild Synovitis Impairs Chondrogenic Joint Environment.

Sharada Paudel1, Tyler Feltham2, Lumanti Manandhar3

  • 1Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

Cells, Tissues, Organs
|July 31, 2023
PubMed
Summary
This summary is machine-generated.

Mild synovitis negatively impacts cartilage repair by inhibiting chondrocyte matrix production. This finding highlights the importance of addressing synovitis for effective joint healing.

Keywords:
ChondrocyteChondrogenesisFibroblast-like synoviocyteSynovitisSynovium

More Related Videos

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

3.8K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.2K

Related Experiment Videos

Last Updated: Jul 20, 2025

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

20.8K
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

3.8K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.2K

Area of Science:

  • Orthopedics
  • Rheumatology
  • Cell Biology

Background:

  • The role of mild synovitis in cartilage repair is often overlooked.
  • Synovitis, inflammation of the synovial membrane, can affect the joint's healing environment.
  • Fibroblast-like synoviocytes (FLSs) play a crucial role in joint homeostasis and inflammation.

Purpose of the Study:

  • To investigate the impact of mild synovitis on chondrogenesis.
  • To determine the effect of fibroblast-like synoviocytes (FLSs) from synovitic joints on chondrocyte function.
  • To assess the relationship between synovitis severity and chondrocyte matrix production.

Main Methods:

  • Histological analysis of 21 synovial samples (13 normal, 8 mild synovitis).
  • Isolation and culture of fibroblast-like synoviocytes (FLSs).
  • Culture of chondrocytes with conditioned medium from FLSs and assessment of glycosaminoglycan production.

Main Results:

  • Mild synovitis was characterized by increased CD3+ lymphocytes in the sublining layer.
  • Chondrocytes treated with conditioned medium from FLSs showed reduced glycosaminoglycan production.
  • Glycosaminoglycan production was negatively correlated with synovitis scores.

Conclusions:

  • Mild synovitis compromises chondrogenesis by inhibiting chondrocyte matrix production via FLSs.
  • Even mild synovitis significantly alters the joint environment, impairing cartilage repair outcomes.
  • Targeting synovitis may be crucial for improving cartilage repair strategies.