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The Three-Chamber Choice Behavioral Task using Zebrafish as a Model System
Published on: April 14, 2021
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Towards experimental models of delirium utilizing zebrafish
Gleb O Maslov1, Konstantin N Zabegalov2, Konstantin A Demin3
1Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Ural Federal University, Ekaterinburg, Russia.
Behavioural Brain Research
|July 31, 2023
Summary
Zebrafish offer a novel model for studying delirium, a complex neuropsychiatric condition. Their genetic and physiological similarities to mammals make them valuable for understanding delirium causes and developing new treatments.
Area of Science:
- Neuroscience
- Pharmacology
- Animal Models
Background:
- Delirium is an acute neuropsychiatric condition with poorly understood central nervous system (CNS) mechanisms and risk factors.
- Rodent models are widely used, but novel organisms are needed to advance delirium research.
- Zebrafish (Danio rerio) present a promising alternative model organism.
Purpose of the Study:
- To critically discuss the utility of zebrafish as a model organism for studying delirium.
- To highlight recent developments in zebrafish models for delirium research.
- To emphasize the potential of zebrafish for translational studies of delirium and related drugs.
Main Methods:
- Review of recent scientific literature on zebrafish models for delirium.
- Discussion of zebrafish genetic and physiological homology to mammals.
- Evaluation of zebrafish behavioral testing and drug screening capabilities.
Main Results:
- Zebrafish exhibit high genetic and physiological homology to mammals.
- They are easily maintained and display robust behaviors suitable for sensitive testing.
- The species offers potential for high-throughput screening of pharmacological agents relevant to delirium.
Conclusions:
- Zebrafish are a valuable and promising aquatic model for understanding delirium etiology.
- This model can aid in the development of novel therapeutic strategies for delirium.
- Zebrafish research facilitates translational studies for delirium and deliriant drugs.
