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Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective

Xingui Tian1, Xiao Li1, Shuyan Qiu1

  • 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510182, China.

Virologica Sinica
|July 31, 2023
PubMed

Insights

Human adenovirus (HAdV) infections can cause abnormal liver function in children. Specific types, HAdV-7 and HAdV-55, may be under-recognized causes of hepatitis in pediatric patients.

Area of Science:

  • Pediatric Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Human adenoviruses (HAdVs) are known to cause acute hepatitis in immunocompromised individuals.
  • The role of HAdVs in hepatitis among immunocompetent children remains unclear.

Purpose of the Study:

  • To investigate the association between adenovirus infection and liver function abnormalities in hospitalized children.
  • To identify specific HAdV types that may contribute to hepatitis in pediatric populations.

Main Methods:

  • Retrospective analysis of liver function test (LFT) results in children (<14 years) hospitalized for adenovirus-associated acute respiratory infection.
  • Comparison of LFT parameters between different HAdV serotypes (HAdV-3, HAdV-7, HAdV-55).
  • Analysis of serial LFT data in a subset of patients.

Main Results:

  • Elevated alanine transaminase (ALT) and aspartate aminotransferase (AST) levels were observed in 7.74% and 46.89% of patients, respectively.
  • HAdV-7 and HAdV-55 infections were associated with significant elevations in ALT, AST, gamma-glutamyl transpeptidase (γ-GT), and bilirubin levels.
  • HAdV-7 infection showed higher ALT, AST, γ-GT, and lower albumin compared to HAdV-3.
  • HAdV-55 infection resulted in higher γ-GT, total bilirubin, and direct bilirubin compared to other types.

Conclusions:

  • Adenovirus infection is frequently associated with abnormal liver function in children.
  • HAdV-7 and HAdV-55 are potential, under-recognized contributors to hepatitis in immunocompetent children.
  • Abnormal liver function indicators can persist throughout hospitalization in affected children.

Keywords:
Acute respiratory diseaseAdenovirusHepatitisLiver enzymeLiver function test

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