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The weight of obesity in hypertrophic cardiomyopathy

Marina Zaromytidou1, Konstantinos Savvatis2

  • 1Barts Health NHS Trust, London, UK marina.zaromytidou@nhs.net.

Clinical Medicine (London, England)
|July 31, 2023
PubMed

Insights

Obesity may worsen outcomes in hypertrophic cardiomyopathy (HCM), a genetic heart muscle disease. This review explores obesity's impact on HCM phenotypes, symptoms, and management strategies.

Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Diseases

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary inherited heart muscle disease caused by sarcomere protein genetic mutations.
  • Clinical heterogeneity in HCM, even within families, suggests environmental factors influence disease presentation.
  • Obesity is linked to adverse cardiovascular outcomes and shares pathophysiological traits with HCM.

Approach:

  • This review synthesizes current knowledge on the effects of obesity in HCM.
  • It examines how obesity impacts cardiac phenotype, clinical symptoms, and treatment approaches.
  • The focus is on understanding the interplay between obesity and hypertrophic cardiomyopathy.

Key Points:

  • Obesity is prevalent in HCM patients and may exacerbate cardiac dysfunction.
  • Shared pathophysiological mechanisms between obesity and HCM warrant further investigation.
  • Understanding obesity's role is crucial for personalized HCM management.

Conclusions:

  • Obesity significantly influences the cardiac phenotype and clinical course of hypertrophic cardiomyopathy.
  • Further research is needed to elucidate the specific mechanisms by which obesity affects HCM.
  • Integrating weight management into HCM care may improve patient outcomes.

Keywords:
BMIbariatricdisease modifiershypertrophic cardiomyopathyobesity

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