Related Experiment Video
Updated: Jul 20, 2025
06:22
In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
Published on: July 29, 2019
13.9K
Quantifying the relationship between spreading depolarization and perivascular cerebrospinal fluid flow.
Saikat Mukherjee1,2, Mahsa Mirzaee3, Jeffrey Tithof3
1Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA. saikatm@iastate.edu.
Scientific Reports
|July 31, 2023
Summary
Spreading depolarization (SD) increases cerebrospinal fluid (CSF) flow in brain perivascular spaces (PVSs). Our model reveals CSF flow depends on PVS dimensions and SD wave characteristics, offering new insights into brain fluid dynamics.
Area of Science:
- Neuroscience
- Biophysics
- Computational Biology
Background:
- Spreading depolarization (SD) is an electro-chemical wave implicated in neurological conditions like stroke and migraine.
- Previous research suggests a link between SD events and increased cerebrospinal fluid (CSF) flow within the brain's perivascular spaces (PVSs).
Purpose of the Study:
- To develop and utilize a novel computational model that couples the dynamics of spreading depolarization (SD) with cerebrospinal fluid (CSF) flow.
- To quantitatively investigate how SD influences CSF flow through the perivascular spaces (PVSs).
Main Methods:
- Employed high-order numerical simulations to solve reaction-diffusion equations governing ionic dynamics during SD.
- Developed a 1D CSF flow model integrated with the SD model via an empirical relationship linking extracellular potassium concentration to vessel radius.
- Derived analytical expressions for CSF pressure and flow rates and analyzed scenarios involving colliding SD waves.
Main Results:
- Demonstrated that CSF volumetric flow rate is intricately dependent on PVS dimensions (length, width), vessel radius, and the angle of SD wave incidence.
- Quantified variations in CSF flow, particularly when two SD waves interact.
- Established analytical expressions for pressure and volumetric flow rates.
Conclusions:
- The developed computational model provides a quantitative framework for understanding the coupling between SD and CSF flow.
- Findings highlight the complex interplay of factors influencing brain fluid dynamics during SD events.
- The model's generality allows for future extensions to explore other neurophysiological phenomena impacting CSF flow.
Related Concept Videos
01:21Cerebrospinal Fluid
2.4K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
2.4K
01:27Regulation of Stroke Volume
3.3K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.3K