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Related Experiment Video

Updated: Jul 20, 2025

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

Human Breast Milk Omics and Neurodevelopment.

Eleni Papakonstantinou¹, Panagiotis Vlamos², Flora Bacopoulou³

¹Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.

Advances in Experimental Medicine and Biology

|July 31, 2023

Summary

This summary is machine-generated.

This study uses multi-omics to analyze breast milk, identifying key molecules for infant health and exploring ways to improve milk synthesis. The goal is to define breast milk

Keywords:

Breast cancer Exosomes Milk Neurodevelopment Omics Pathology lncRNAs

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Area of Science:

* Biochemistry and Molecular Biology
* Genomics and Proteomics
* Infant Nutrition and Development

Background:

* Breast milk offers significant immediate and long-term health benefits for infants, including protection against infections and improved neurodevelopment.
* Components like nutrients, immune factors, and extracellular vesicles contribute to these benefits.
* Understanding the molecular composition is crucial for optimizing infant health and potentially improving milk products.

Purpose of the Study:

* To comprehensively analyze breast milk using multi-omics technologies.
* To identify and validate novel biomarkers (ncRNAs and proteins) for infant health.
* To explore methods for enhancing milk synthesis and commercial milk products.

Main Methods:

* Application of functional genomics, comparative genomics, transcriptomics, sequencing, proteomics, and metabolomics.
* Systems biology and bioinformatics for data integration and analysis.
* Validation of candidate biomarkers in exosomes from breast milk and blood/serum samples.

Main Results:

* Generation of a detailed molecular fingerprint of breast milk.
* Identification of important long non-coding RNAs (lncRNAs) and protein molecules as potential biomarkers.
* Exploration of cross-species milk analysis (bovine, goat, sheep) for insights into milk synthesis.

Conclusions:

* Multi-omics analysis provides a holistic understanding of breast milk's complex composition.
* Validated biomarkers can aid in assessing infant health and development.
* Findings may lead to improvements in infant nutrition and the development of enhanced commercial milk products.