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Association between AGTR1 (c.1166 A>C) Polymorphisms and Kidney Injury in Hypertension

Yiyao Zeng1,2, Yufeng Jiang1,2, Ziyin Huang1,2

  • 1Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, 215000 Suzhou, Jiangsu, China.

Frontiers in Bioscience (Landmark Edition)
|August 1, 2023
PubMed

Insights

This study found a link between the AGTR1 gene (c.1166 A>C) polymorphism and hypertension with kidney damage. Understanding these genetic variations may aid in precision gene therapy for hypertension.

Area of Science:

  • Genetics
  • Cardiology
  • Nephrology

Background:

  • High blood pressure is a leading cause of cardiovascular diseases.
  • Kidney damage is a common secondary complication of hypertension.
  • Investigating hypertension gene polymorphisms is crucial for precision treatment.

Purpose of the Study:

  • To explore the association between AGTR1 (c.1166 A>C) gene polymorphisms and hypertension with kidney damage.
  • To examine different genetic models (codominant, dominant, recessive) and their relation to hypertension and kidney injury.
  • To assess the susceptibility of various genotypes to hypertension with kidney injury.

Main Methods:

  • The study involved 292 hypertensive patients and 44 with hypertension and kidney injury.
  • AGTR1 polymorphism distribution was analyzed using the PCR-melting curve method.
  • Genotype distributions were compared between groups.

Main Results:

  • Genotype distributions in hypertension and combined groups adhered to Hardy-Weinberg equilibrium (p > 0.05).
  • Statistically significant differences were observed in the distribution of three genotypes (p < 0.05).
  • Codominant, dominant, and recessive genotype frequencies showed significant differences (p < 0.05), with no significant difference between A and C alleles (p > 0.05).

Conclusions:

  • The AGTR1 (c.1166 A>C) polymorphism is associated with hypertension combined with renal injury.
  • Comparison of different genetic models provides insights into susceptibility.
  • Findings may offer new targets for precision gene therapy in hypertension management.
Abstract

Keywords:
AGTR1genetic polymorphism 24hypertensionrenal injury

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