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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Giovanni Tossetta1, Sonia Fantone1, Daniela Marzioni1

  • 1Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy.

Frontiers in Bioscience (Landmark Edition)
|August 1, 2023
PubMed

Insights

This review explores the Nuclear factor erythroid 2-related factor 2 (NRF2)/Kelch Like ECH Associated Protein 1 (KEAP1) pathway in prostate cancer. It identifies indirect modulators of this pathway as potential therapeutic targets for advanced disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Prostate cancer is a leading global malignancy in men.
  • Androgen-deprivation therapy is crucial for advanced prostate cancer management.
  • Oxidative stress and the NRF2/KEAP1 pathway are implicated in cancer development and progression.

Purpose of the Study:

  • To review the current literature on indirect modulators of the NRF2/KEAP1 pathway in prostate cancer.
  • To explore the role of these modulators as potential therapeutic targets.

Main Methods:

  • Literature review of studies investigating the NRF2/KEAP1 pathway in prostate cancer.
  • Analysis of indirect modulators affecting NRF2/KEAP1 signaling.
  • Examination of the pathway's relevance to anti-androgen therapy, recurrence, and radiotherapy.

Main Results:

  • The NRF2/KEAP1 pathway is influenced by reactive oxygen species (ROS).
  • This pathway is linked to anti-androgen therapy, biochemical recurrence, and radiotherapy in prostate cancer.
  • Several indirect modulators of the NRF2/KEAP1 pathway have been identified.

Conclusions:

  • Indirect modulators of the NRF2/KEAP1 pathway represent promising therapeutic targets for prostate cancer.
  • Targeting these modulators may offer novel treatment strategies for advanced prostate cancer.
Keywords:
KEAPNRF2antioxidantschemotherapymodulatorprostate cancersignaling

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