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Updated: Jul 20, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Investigational drugs for the treatment of scleroderma: what's new?

Jelena Colic1, Corrado Campochiaro2,3, Michael Hughes4

  • 1Department of Rheumatology, Institute of Rheumatology, Belgrade, Serbia.

Expert Opinion on Investigational Drugs
|August 1, 2023
PubMed
Abstract

Insights

Systemic sclerosis (SSc) is a deadly fibrotic disease. This review examines new targeted therapies in early trials to improve treatment outcomes and prevent irreversible damage.

Area of Science:

  • Immunology
  • Rheumatology
  • Fibrotic Diseases

Background:

  • Systemic sclerosis (SSc) is a rare, chronic autoimmune fibrotic disease with high mortality.
  • It is characterized by progressive fibrosis affecting skin and internal organs.
  • Despite advances, early diagnosis and treatment remain challenging.

Purpose of the Study:

  • To systematically review emerging targeted therapies for Systemic Sclerosis.
  • Focus on Phase I and II clinical trials from the past three years.
  • Assess the impact of these therapies on disease progression.

Main Methods:

  • Systematic literature review.
  • Focus on Phase I and II clinical trials.
  • Analysis of data published within the last three years.

Main Results:

  • The review focuses on ongoing research and early-phase trials.
  • Identified emerging targeted therapies and their potential impact.
  • Highlights the need for further investigation into novel pathways.

Conclusions:

  • Early diagnosis and intervention are critical for preventing irreversible SSc damage.
  • New molecular and epigenetic research offers hope for personalized treatment strategies.
  • Continued investigation into targeted therapies is essential for improving SSc patient outcomes.
Keywords:
clinical trialsinvestigational drugspathogenesissystemic sclerosistargeted therapy

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