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Related Experiment Video

Updated: Jul 20, 2025

Comet Assay as an Indirect Measure of Systemic Oxidative Stress
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Selenium, Selenoproteins and 10-year Cardiovascular Risk: Results from the ATTICA Study.

Paraskevi Detopoulou1, Sophia Letsiou1, Tzortzis Nomikos1

  • 1Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.

Current Vascular Pharmacology
|August 1, 2023
PubMed
Summary

Total selenium in selenoproteins is linked to increased cardiovascular disease risk. Specific selenoprotein levels, like glutathione peroxidase 3 (GPx3), are crucial for managing this risk.

Keywords:
ATTICA studyGPx3Seleniumcardiovascular disease.selenoprotein Pselenoproteinsspeciation

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Cardiovascular Research

Background:

  • Selenium (Se) is an essential trace element with diverse pathophysiological roles.
  • The precise relationship between selenium and cardiovascular disease (CVD) risk, particularly concerning different selenospecies, remains unclear.

Purpose of the Study:

  • To investigate the association between plasma selenoprotein levels (GPx3, SelP, SeAlb) and total selenium distribution with 10-year cardiovascular risk.
  • To explore the role of specific selenoproteins in modulating CVD risk within the ATTICA prospective study.

Main Methods:

  • Analysis of a sub-sample (n=278) from the ATTICA Study with baseline selenium and selenoprotein data.
  • Quantification of plasma SeGPx3, SelP, and SeAlb using HPLC-ICP-MS.
  • Cox proportional hazards models were used to assess the relationship between selenium levels and cardiovascular outcomes over an average follow-up of 8.74 years.

Main Results:

  • Total selenium in selenoproteins showed a positive association with 10-year cardiovascular disease risk.
  • Individuals with high total selenium but low glutathione peroxidase 3 (GPx3) exhibited a significantly higher cardiovascular risk.

Conclusions:

  • Circulating selenoprotein levels have differential effects on cardiovascular disease risk.
  • Redox regulation by specific selenoproteins, such as GPx3, is critical in cardiovascular health and disease prevention.