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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Introduction to Electrolytes01:33

Introduction to Electrolytes

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In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Pedigree Analysis01:35

Pedigree Analysis

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Pediatric vitamin D: Pseudo-hypervitaminosis.

Lily Olayinka1,2, Izmarie Poventud-Fuentes1,2, Emily Garnett1,2

  • 1Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.

Journal of Clinical Laboratory Analysis
|August 1, 2023
PubMed
Summary

Falsely elevated vitamin D levels in children can occur due to immunoassay variations. A simple centrifugation step before testing can resolve these measurement discrepancies, ensuring accurate vitamin D assessment.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Chemistry
  • Laboratory Medicine

Background:

  • Vitamin D toxicity is uncommon in children.
Keywords:
25-hydroxyvitamin Darchitect i2000SRimmunoassaysliquid chromatography-tandem mass spectrometryvitamin D assays

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  • Immunoassay methods can yield falsely elevated 25-hydroxyvitamin D levels, posing diagnostic challenges.
  • Accurate quantification of vitamin D metabolites is crucial for pediatric health.