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Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
Biochemical and Hematologic Profiles in B-Cell Acute Lymphoblastic Leukemia Children
Ammara Khalid1, Mehboob Ahmed, Shahida Hasnain
1Institute of Microbiology and Molecular Genetics, University of the Punjab, Quaid e Azam Campus, Lahore, Pakistan.
Insights
This study analyzed hematological and biochemical profiles in pediatric B-cell acute lymphoblastic leukemia (B-ALL). Key findings reveal altered blood counts and significant biochemical differences based on sex and age in B-ALL patients.
Area of Science:
- Pediatric Oncology
- Hematology
- Clinical Biochemistry
Background:
- B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood leukemia.
- Prognostic factors for childhood leukemia include diagnosis timing, white blood cell count, age, and sex.
- Hematological and biochemical profiles are vital for assessing patient health before and after chemotherapy.
Purpose of the Study:
- To evaluate hematological and biochemical parameters in pediatric B-ALL cases.
- To compare these parameters against normal reference values.
- To identify potential correlations with prognostic factors like age and sex.
Main Methods:
- Analysis of 200 pediatric B-ALL cases.
- Assessment of complete blood count (CBC) and white blood differential count.
- Evaluation of renal function tests, liver function tests, serum electrolytes, and serum proteins.
Main Results:
- Most cases were males under 5 years of age.
- Hematology revealed lower red blood cells, hemoglobin, and platelets, with higher white blood cells compared to normal.
- Biochemical profiles showed significant sex- and age-based differences, while hematological profiles did not exhibit significant variations.
Conclusions:
- Pediatric B-ALL patients exhibit distinct hematological and biochemical profiles.
- Biochemical parameters show significant variability influenced by sex and age.
- These findings underscore the importance of comprehensive profiling for B-ALL management.
Abstract:
B-cell acute lymphoblastic leukemia is the most common type of leukemia found in children. Timely diagnosis, white blood cell count, age of onset, and sex are considered the most important prognostic factors in childhood leukemia. Hematological and biochemical profiles are crucially important to infer the health of leukemia patient pre-chemotherapy and post-chemotherapy treatment. In the current study 200 cases were taken and evaluated for hematological (complete blood count and white blood differential count) and biochemical parameters (renal function tests, liver function tests, serum electrolytes and serum proteins) by comparison with normal reference values. Most of the cases were male under 5 years of age. Hematology parameters including red blood cells, hemoglobin and platelet levels were relatively low whereas white blood cells level was high in cases as compared with normal reference value. Sex-wise and age-wise comparison of biochemical profile showed significant difference among B-cell acute lymphoblastic leukemia cases whereas hematological profile did not show any visible difference.
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