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Related Experiment Videos

Massive diltiazem overdose.

S W Snover, V Bocchino

    Annals of Emergency Medicine
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    A 74-year-old man experienced a severe diltiazem overdose, leading to cardiac asystole. Emergency transvenous pacing successfully managed this critical event, highlighting the importance of prompt intervention in calcium channel blocker toxicity.

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    Area of Science:

    • Cardiology
    • Clinical Toxicology
    • Emergency Medicine

    Background:

    • Diltiazem is a widely used calcium channel blocker for cardiovascular conditions.
    • Overdoses can lead to significant hemodynamic compromise, including bradycardia and asystole.
    • Accidental medication errors are a concern, particularly in elderly patients with cognitive impairment and visual deficits.

    Observation:

    • A 74-year-old male patient presented with symptoms of bradycardia, diaphoresis, confusion, and slurred speech.
    • The patient developed asystole, a life-threatening cardiac arrest rhythm.
    • The patient's medical history included blindness and chronic confusion.

    Findings:

    • The patient had ingested approximately 1,500 mg of diltiazem, a significant overdose.

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  • The overdose was attributed to a medication error stemming from the patient's visual and cognitive impairments.
  • Successful resuscitation was achieved with temporary emergency transvenous pacing, ventilation, and blood pressure support.

    • Implications:

    • This case underscores the critical need for vigilant medication management in elderly patients with cognitive deficits.
    • Prompt recognition and intervention, including advanced cardiac life support, are crucial for managing severe diltiazem toxicity.
    • Enhanced patient safety protocols are necessary to prevent medication errors in vulnerable populations.