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Causal relationships between obesity and pancreatobiliary diseases: a two-sample Mendelian randomization study
Dan Huang1, Yu Liu1, Wenjun Gong1
1Department of Clinical Pharmacy, The People's Hospital of Pengzhou, No. 255 Second section of South Third Ring Road, Chengdu, China.
Eating and Weight Disorders : EWD
|August 1, 2023
Summary
General and abdominal obesity causally increase the risk of pancreatobiliary diseases. Weight loss is recommended to prevent these conditions, as indicated by body mass index (BMI) and waist circumference (WC) findings.
Area of Science:
- Gastroenterology and Hepatology
- Genetics and Epidemiology
Background:
- Observational studies suggest a link between obesity and pancreatobiliary diseases.
- Causality between obesity metrics and these diseases remains unconfirmed.
Purpose of the Study:
- To investigate the causal relationship between obesity indicators (BMI, WC, HC, WHR) and pancreatobiliary diseases using Mendelian Randomization.
- To provide evidence-based recommendations for disease prevention.
Main Methods:
- Two-Sample Mendelian Randomization (MR) analysis utilizing genome-wide association study (GWAS) data.
- Inverse variance weighted (IVW) method for causal effect estimation.
- Heterogeneity and pleiotropy assessed using Cochran's Q test, MR-Egger regression, and MR-PRESSO.
Main Results:
- A significant positive causal effect of body mass index (BMI) on pancreatobiliary diseases (OR: 1.021; P < 5x10^-15).
- A significant positive causal effect of waist circumference (WC) on pancreatobiliary diseases (OR: 1.021; P < 2x10^-10).
- No causal relationship found between hip circumference (HC), waist-to-hip ratio (WHR), and pancreatobiliary diseases.
Conclusions:
- General obesity (BMI) and abdominal obesity (WC) are causally linked to an increased risk of pancreatobiliary diseases.
- Interventions aimed at reducing BMI and WC may be effective in preventing these diseases.
- HC and WHR are not identified as causal risk factors in this analysis.
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