Related Experiment Video
Updated: Jul 20, 2025
09:16
Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
Published on: June 26, 2018
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Synucleinopathies: Intrinsic and Extrinsic Factors
Alma Karen Lomeli-Lepe1, Jose Luis Castañeda-Cabral1, Silvia Josefina López-Pérez2
1Departamento de Biología Celular y Molecular, CUCBA, Universidad de Guadalajara, Guadalajara, JAL, México.
Cell Biochemistry and Biophysics
|August 1, 2023
Summary
Epigenetic regulation of the alpha-synuclein (α-syn) gene influences neurodegenerative diseases. This review explores how epigenetic changes interact with other factors to promote α-syn aggregation in synucleinopathies.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- α-Synucleinopathies are neurodegenerative disorders linked to alterations in the α-synuclein (α-syn) protein.
- The precise function of α-syn in normal cells remains unclear, but its gene regulation is central to disease pathology.
- These complex disorders arise from interactions between genetic and environmental factors.
Purpose of the Study:
- To provide an updated overview of epigenetic regulation of α-syn gene expression in α-synucleinopathies.
- To examine the interplay between epigenetic modifications and other disease-related factors.
- To elucidate mechanisms promoting α-syn aggregation via gene transcription and translation.
Main Methods:
- Literature review and synthesis of current research on epigenetic mechanisms.
- Analysis of the influence of posttranslational modifications, microbiota, lipids, neuroinflammation, and oxidative stress.
- Focus on transcriptional and translational regulation of the α-syn gene.
Main Results:
- Epigenetic modifications significantly impact α-syn gene expression, contributing to α-synucleinopathies.
- Interactions between epigenetic factors and cellular processes like neuroinflammation and oxidative stress promote α-syn aggregation.
- The study highlights the complex network influencing α-syn pathology.
Conclusions:
- Epigenetic regulation is a critical factor in the pathogenesis of α-synucleinopathies.
- Understanding these epigenetic influences offers potential therapeutic targets.
- Further research into the multifaceted interactions governing α-syn aggregation is warranted.
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