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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Electroconvulsive Therapy01:30

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

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Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
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Related Experiment Video

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Economic Evaluation Associated With Clinical-Grade Mobile App-Based Digital Therapeutic Interventions: Systematic

Yoann Sapanel1, Xavier Tadeo1,2, Connor T A Brenna3

  • 1The Institute for Digital Medicine WisDM, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Journal of Medical Internet Research
|August 1, 2023
PubMed
Summary

Digital therapeutics (DTx) show economic benefits, but methodological flaws in current cost-effectiveness studies create uncertainty. Future research must address these limitations for wider DTx adoption.

Keywords:
cost-effectivenessdigital healthdigital therapeuticseconomic evaluationmobile phonesystematic review

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Area of Science:

  • Digital Health
  • Health Economics
  • Clinical Interventions

Background:

  • Digital therapeutics (DTx) are software-based interventions with potential for disease management and healthcare scalability.
  • The COVID-19 pandemic accelerated DTx adoption, increasing awareness among stakeholders.
  • The economic value of DTx in healthcare remains largely underexplored.

Purpose of the Study:

  • To systematically review and summarize evidence on the cost-effectiveness of mobile app-based DTx.
  • To identify factors influencing the economic evaluations of DTx.

Main Methods:

  • Systematic review following PRISMA 2020 guidelines.
  • Searched major databases (PubMed, Cochrane, Web of Science) for economic evaluations of DTx.
  • Assessed methodological quality and risk of bias of included studies.

Main Results:

  • 18 studies were included: 7 nonrandomized, 6 model-based, 5 RCT-based.
  • DTx interventions were cost-effective in 67% of studies and cost-saving in 28%.
  • Methodological deficiencies and bias risks were noted in several studies.

Conclusions:

  • DTx interventions demonstrate potential economic benefits.
  • Current economic analyses of DTx suffer from methodological shortcomings.
  • Addressing these limitations is crucial for reducing uncertainty and promoting DTx adoption.