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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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The association between CHA2DS2-VASc score and aortic valve sclerosis

Funda Başyiğit1, Havva Tuğba Gürsoy1, Özlem Özcan Çelebi1

  • 1Department of Cardiology, Ankara City Hospital, Ankara, Turkey.

Cardiovascular Journal of Africa
|August 1, 2023
PubMed

Insights

Aortic valve sclerosis (AVS) is linked to higher CHA2DS2-VASc scores, indicating increased cardiovascular risk. This finding suggests AVS may serve as a predictor for cardiovascular events in the general population.

Area of Science:

  • Cardiology
  • Valvular Heart Disease
  • Thrombosis

Background:

  • Antithrombotic therapy for atrial fibrillation commonly utilizes the CHA2DS2-VASc score.
  • Aortic valve sclerosis (AVS) involves aortic valve thickening without motion restriction and is associated with cardiovascular risk factors.

Purpose of the Study:

  • To investigate the association between the presence of aortic valve sclerosis (AVS) and the CHA2DS2-VASc score.

Main Methods:

  • A cross-sectional, observational study included 411 patients with AVS (grades 1-3) and 102 patients without AVS (grade 0).
  • CHA2DS2-VASc scores were compared between patients with and without AVS.

Main Results:

  • The group with AVS exhibited significantly higher CHA2DS2-VASc scores compared to the group without AVS (median 3 vs. 1, p < 0.001).

Conclusions:

  • Patients with aortic valve sclerosis have a higher CHA2DS2-VASc score.
  • AVS may serve as a potential predictor of cardiovascular risk in the general population.
Abstract

Keywords:
aortic valveatherosclerosiscoronary artery diseaseinflammation

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