Related Experiment Video

Updated: Jul 20, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

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Neonatal complicated intraabdominal infection

Jessica L Rauh1, Alison J Lehane1, Leah M Sieren2

  • 1Wake Forest School of Medicine, General Surgery.

Current Opinion in Infectious Diseases
|August 1, 2023
PubMed

Insights

Treatment for complicated intra-abdominal infections (cIAIs) in premature infants involves surgery and antibiotics. Ongoing research aims to improve outcomes for these challenging cases, focusing on necrotizing enterocolitis (NEC).

Area of Science:

  • Neonatal Medicine
  • Pediatric Surgery
  • Infectious Diseases

Background:

  • Complicated intra-abdominal infections (cIAIs) and necrotizing enterocolitis (NEC) pose significant challenges in premature infants.
  • Recent research has elucidated the roles of the microbiome, breast milk, and specific risk factors in NEC development.
  • Understanding the complex pathophysiology of cIAIs in this vulnerable population is crucial for effective management.

Approach:

  • This review synthesizes current understanding of cIAI treatment in premature neonates.
  • It examines the interplay between surgical interventions and medical management, including antibiotic selection.
  • The review also highlights emerging research and future directions in NEC treatment strategies.

Key Points:

  • Optimal treatment for cIAIs necessitates a combined surgical and medical approach.
  • The type and timing of surgical intervention, alongside appropriate antibiotic regimens, are critical components of care.
  • Advances in understanding NEC pathogenesis are guiding new therapeutic avenues.

Conclusions:

  • Complicated intra-abdominal infections in premature infants represent a difficult clinical problem requiring further investigation.
  • Continued research is essential to refine treatment protocols and improve patient outcomes.
  • Future directions focus on novel therapeutic strategies for NEC and related cIAIs.
Abstract

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