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Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Related Experiment Video

Updated: Jul 20, 2025

Pattern-based Search of Epigenomic Data Using GeNemo
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Full-Privacy Secured Search Engine Empowered by Efficient Genome-Mapping Algorithms.

Yuan-Yu Chang, Sheng-Tang Wong, Emmanuel O Salawu

    IEEE Journal of Biomedical and Health Informatics
    |August 1, 2023
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces Sapiens Aperio Veritas Engine (S.A.V.E.), a novel search method using full articles as queries. S.A.V.E. ensures user privacy by not disclosing search content, offering a secure alternative to traditional search engines.

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    Area of Science:

    • Computer Science
    • Information Retrieval
    • Bioinformatics

    Background:

    • Traditional search engines rely on keyword queries, exposing user data and search history.
    • Existing search methods lack robust privacy protections, often utilizing user data for targeted advertising or database expansion.

    Purpose of the Study:

    • To introduce a novel search and plagiarism detection system, Sapiens Aperio Veritas Engine (S.A.V.E.), that prioritizes user privacy.
    • To enable users to search the internet and perform plagiarism checks using full articles as queries without revealing content.

    Main Methods:

    • Developed S.A.V.E., employing an encoding scheme and FM-index search adapted from next-generation genome sequencing.
    • Transformed query words into a pseudo-biological sequence (PBS) using 12 "amino acids" on the user's device.
    • Utilized cloud service for plagiarism checks by submitting locally generated PBSs against a database of Wikipedia and Open Access journals.

    Main Results:

    • S.A.V.E. accurately detects identical content with less than 0.8% false positives for PBSs longer than 12 "amino acids".
    • The system achieves genome-mapping speeds comparable to Bowtie and is over 5 orders of magnitude faster than BLAST.
    • S.A.V.E. offers both standard and private search modes, enhancing user confidentiality.

    Conclusions:

    • S.A.V.E. presents a revolutionary, privacy-first search and plagiarism check system.
    • The method sets a precedent for future search engines designed with user confidentiality as a priority.
    • The system is accessible at https://dyn.life.nthu.edu.tw/SAVE/.