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Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy

Zeena Gadsby1, Jack Garland2, Melissa Thompson

  • 1From the Griffith University School of Medicine, Southport, Queensland, Australia.

The American Journal of Forensic Medicine and Pathology
|August 1, 2023
PubMed

Insights

The number of binucleated myocytes may help assess heart hypertrophy when heart weight is difficult to measure. This preliminary study found a significant association in males, suggesting a complementary role for myocyte analysis.

Area of Science:

  • Cardiovascular Pathology
  • Histopathology

Background:

  • Heart hypertrophy is typically assessed using heart weight and myocyte size.
  • An association between these measures could aid hypertrophy assessment when heart weight is limited.

Purpose of the Study:

  • To explore the association between binucleated myocytes and heart weight.
  • To compare binucleated myocyte counts in normal versus enlarged hearts.

Main Methods:

  • Examined left ventricular free wall tissue from an adult White population.
  • Quantified binucleated myocytes in a single high-power field.
  • Correlated myocyte counts with heart weight, comparing normal and increased heart weight groups.

Main Results:

  • A significant correlation between heart weight and binucleated myocytes was found in males only.
  • Hearts with increased weight showed significantly more binucleated myocytes.
  • A threshold of 8.5 binucleated myocytes demonstrated 74% sensitivity and 79% specificity for identifying increased heart weight.

Conclusions:

  • The number of binucleated myocytes may serve as a complementary indicator for assessing cardiac hypertrophy.
  • This finding is particularly relevant in situations where direct heart weight measurement is challenging.

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