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Toward Property-Based Regulation.

Tobias D Muellers1,2, Predrag V Petrovic1,2, Julie B Zimmerman1,2

  • 1School of the Environment, Yale University, 195 Prospect St, New Haven, Connecticut 06511, United States.

Environmental Science & Technology
|August 1, 2023
PubMed
Summary

Current chemical regulation is slow and inefficient. A new property-based regulatory approach can improve safety assessments, speed up regulation, and enhance transparency for chemical designers.

Keywords:
Physicochemical propertieschemical assessmentchemical regulationmolecular design for reduced hazardsafe chemical space

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Area of Science:

  • Environmental chemistry
  • Toxicology
  • Regulatory science

Background:

  • Anthropogenic chemicals cause widespread environmental and health issues.
  • Current chemical regulation is chemical-identity based, proving insufficient and inefficient.
  • This approach allows adverse impacts to persist due to slow regulatory action.

Purpose of the Study:

  • To introduce a novel regulatory paradigm: property-based regulation.
  • To demonstrate how regulating physicochemical properties can create safe chemical spaces.
  • To enhance the scalability and efficiency of chemical assessments and regulation.

Main Methods:

  • Analyzing the link between fundamental physicochemical properties and chemical hazards.
  • Examining existing sparse property-based regulatory approaches.
  • Using bioaccumulation as a case study to demonstrate applicability.

Main Results:

  • Property-based regulation offers increased scalability for chemical assessments.
  • This approach significantly reduces the time and resources needed for regulation.
  • It provides greater transparency for chemical designers and industry.

Conclusions:

  • Transitioning to property-based regulation is feasible and beneficial.
  • This paradigm shift can accelerate regulatory processes for new molecules.
  • Implementation requires collaboration between government, NGOs, and industry.