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Updated: Aug 7, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

[Febrile convulsions and meningitis]

L Echevarría Zudaire, B Pérez López, F García Algas

    Anales Espanoles De Pediatria
    |August 1, 1986
    PubMed

    Insights

    Routine lumbar punctures may not be necessary for infants experiencing their first febrile seizure. Clinical criteria alone can effectively identify meningitis, avoiding unnecessary procedures in many cases.

    Area of Science:

    • Pediatrics
    • Neurology
    • Infectious Diseases

    Context:

    • Febrile seizures are common in infants aged 6-18 months.
    • Diagnosis of meningitis traditionally relies on clinical signs and lumbar puncture.
    • Evaluating the necessity of lumbar puncture in first-time febrile seizures is crucial.

    Purpose:

    • To assess the diagnostic utility of clinical criteria for meningitis in children with first febrile seizures.
    • To evaluate the effectiveness of peripheral white blood cell counts in diagnosing bacterial meningitis.
    • To determine if routine lumbar puncture is warranted in this patient population.

    Summary:

    • A review of 100 clinical records of children (6-18 months) with first febrile seizures was conducted.
    • Lumbar puncture was performed on 42 children, diagnosing meningitis in 4 (2 bacterial).
    • Clinical criteria demonstrated 100% sensitivity and negative predictive value for meningitis, potentially avoiding 40% of lumbar punctures.
    • Peripheral white blood cell counts showed low utility (50% sensitivity) for bacterial meningitis diagnosis.

    Impact:

    • Suggests that clinical assessment alone can be sufficient for managing first febrile seizures in infants.
    • Highlights the potential to reduce invasive procedures like lumbar puncture, minimizing risks and healthcare costs.
    • Informs clinical guidelines regarding the diagnostic workup for meningitis in young children presenting with febrile seizures.

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