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Symptomatic osteoporosis in a man with hyperprolactinemic hypogonadism
Annals of Internal Medicine
|October 1, 1986
Summary
This study highlights that men with osteoporosis should be evaluated for hypogonadism. Hyperprolactinemia can cause hypogonadism, leading to bone loss and other symptoms.
Area of Science:
- Endocrinology
- Bone Metabolism
- Reproductive Health
Background:
- Osteoporosis in men is a significant health concern.
- Hypogonadism is a known risk factor for osteoporosis.
- Hyperprolactinemia can lead to hypogonadism in men.
Observation:
- A 66-year-old man presented with height loss, back pain, and severe osteopenia.
- He had low plasma testosterone and significantly elevated serum prolactin.
- Imaging revealed an invasive pituitary macroadenoma causing secondary empty sella.
Findings:
- Bone histomorphometry indicated low-normal bone volume with normal remodeling rates.
- The patient exhibited symptoms of hyperprolactinemic hypogonadism.
- Treatment with calcium, testosterone, and bromocriptine halted osteoporosis progression.
Implications:
- This case underscores the importance of assessing gonadal function in men with osteoporosis.
- Hyperprolactinemic hypogonadism should be considered in the differential diagnosis of male osteoporosis.
- Early diagnosis and treatment can prevent further bone loss and associated complications.
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