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Related Experiment Videos

Calcium and cardiac arrest.

A Stempien, A M Katz, F C Messineo

    Annals of Internal Medicine
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Calcium's role in heart function is complex. Evidence does not support routine calcium use during cardiac arrest, as it may harm the heart and vascular smooth muscle.

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    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • Calcium regulates cardiac automaticity and myocardial contractility.
    • Calcium increases tension in normal myocardium, leading to its investigation in resuscitation.

    Purpose of the Study:

    • To evaluate the evidence for calcium's benefit in cardiopulmonary resuscitation (CPR).
    • To assess the potential detrimental effects of calcium administration during cardiac arrest.

    Main Methods:

    • Review of existing evidence on calcium's role in cardiac arrest.
    • Analysis of calcium's physiological effects on myocardium and vascular smooth muscle.

    Main Results:

    • Evidence supporting calcium's benefit in cardiac arrest, particularly with electromechanical dissociation or asystole, is lacking.

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  • Cardiac arrest can disrupt myocardial calcium control, leading to overload.
  • Exogenous calcium may exacerbate myocardial and vascular dysfunction.

    • Conclusions:

    • Routine calcium administration in cardiac arrest is not recommended.
    • Potential for calcium overload and adverse effects on the heart and vasculature exists during cardiac arrest.