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Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
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Evolution of Carboxyhemoglobin in Children Supported by Extracorporeal Membrane Oxygenation: An Observational

Orlane Brohan1, Jean-Michel Liet1, Thomas Dejoie2

  • 1From the Service Réanimation Pédiatrique, CHU Nantes, Nantes Université, Réanimation Pédiatrique, Nantes, France.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|August 1, 2023
PubMed

Insights

Carboxyhemoglobin (COHb) levels increase during extracorporeal membrane oxygenation (ECMO) in children. Higher COHb levels can predict ECMO circuit complications, aiding early intervention.

Area of Science:

  • Pediatric critical care medicine
  • Cardiopulmonary support
  • Biomarker research

Background:

  • Carboxyhemoglobin (COHb) is a potential marker for hemolysis and circuit complications during extracorporeal membrane oxygenation (ECMO).
  • Limited data exists on COHb levels in pediatric patients undergoing ECMO.

Purpose of the Study:

  • To investigate COHb levels in children receiving ECMO.
  • To determine if COHb can predict ECMO circuit-related complications in pediatric patients.

Main Methods:

  • Observational, single-center study from January 2018 to December 2021.
  • Included 58 children undergoing ECMO.
  • Measured COHb levels via blood gas analysis before, during, and after ECMO support.

Main Results:

  • COHb levels increased from the 6th hour of ECMO support and remained elevated during and shortly after ECMO.
  • Children experiencing circuit complications showed a significant decrease in COHb levels within 24 hours post-circuit change.
  • Maximal daily COHb levels predicted circuit complications with an ROC curve area of 0.85.

Conclusions:

  • COHb is a potential indicator of hemolysis and circuit-related complications in pediatric ECMO.
  • Monitoring COHb levels may aid in the early detection and management of ECMO complications in children.

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