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Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous

Javier Cervera1, Michael Levin2, Salvador Mafe1

  • 1Dept. Termodinàmica, Facultat de Física, Universitat de València, E-46100 Burjassot, Spain.

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|August 1, 2023
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Summary
This summary is machine-generated.

This study shows how multicellular potentials control cell modules by coupling bioelectricity and gene networks. External actions can correct large-scale bioelectrical patterns for tissue regeneration.

Keywords:
Developmental and regeneration bioelectricityInstructive multicellular patternsMembrane proteinsTranscription regulation

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Area of Science:

  • Cellular bioelectricity
  • Systems biology
  • Biophysics

Background:

  • Cell transmembrane potentials influence signaling ion distribution, guiding downstream pathways in multicellular systems.
  • Bioelectricity and protein transcription are locally coupled, enabling cell modules with shared states to exhibit similar biochemical processes.

Purpose of the Study:

  • To theoretically simulate how multicellular potentials control the integration-segregation patterns of cell modules within a biosystem.
  • To investigate the interplay between bioelectrical and genetic networks in pattern formation.

Main Methods:

  • Coupling model equations of bioelectrical networks with genetic networks.
  • Simulating theoretical control of multicellular module patterns using multicellular potentials.

Main Results:

  • Intercellular junctions and microenvironment coupling facilitate bioelectrical pattern restoration.
  • Restoration achieved by modulating ion channel transcription/blocking and environmental ionic concentrations.

Conclusions:

  • Single-cell bioelectrical-transcriptional feedback, coupled with intercellular and environmental interactions, enables large-scale pattern correction via external interventions.
  • This theoretical framework advances understanding of bioelectric coupling for tissue regeneration and has potential biomedical applications.