Related Experiment Video
Updated: Jul 20, 2025
10:44
Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
Published on: December 9, 2013
12.0K
Sex-Gender-Based Differences in Metabolic Diseases.
Ilaria Campesi1,2, Margherita Ruoppolo3,4, Flavia Franconi2
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Handbook of Experimental Pharmacology
|August 1, 2023
Summary
Sex influences metabolic pathways, leading to different health and disease responses. Metabolomics can uncover sex-based differences in inherited metabolic disorders.
Area of Science:
- Biochemistry
- Genetics
- Metabolomics
Background:
- Sexual dimorphism impacts biological activities and regulatory mechanisms, causing differential health and disease responses.
- Sex-specific genetic and epigenetic factors create physiological metabolic disparities influencing individual phenotypes.
- Sex differences are recognized in disease susceptibility and therapeutic responses, but are understudied in inherited metabolic disorders.
Purpose of the Study:
- To highlight the underappreciated role of sex in inherited metabolic disorders.
- To emphasize the potential of metabolomics in uncovering sex-specific differences in these conditions.
- To advocate for greater consideration of sex in metabolic research and clinical practice.
Main Methods:
- Utilizing advanced metabolomic technologies for comprehensive metabolic profiling.
- Analyzing metabolic data to identify sex-specific patterns and biomarkers.
- Integrating genetic and epigenetic data with metabolomic findings to understand sex influences.
Main Results:
- Metabolomics offers powerful tools for investigating metabolic mechanisms and discovering biomarkers.
- These approaches can effectively reveal sex differences in the context of inborn errors of metabolism.
- Identifying sex-specific metabolic alterations is crucial for understanding disease outcomes and management.
Conclusions:
- Sex is a critical biological variable influencing inherited metabolic disorders.
- Metabolomics provides a promising avenue for elucidating sex-based disparities in metabolism.
- Further research incorporating sex as a factor is essential for advancing diagnostics and therapeutics for metabolic diseases.
Related Concept Videos
01:24Overview of Lipid Metabolism
1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
01:19Factors Affecting Drug Biotransformation: Biological
178
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
178
01:20Pathophysiology of Diabetes
993
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
993
01:24Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
01:19Overview of Carbohydrate Metabolism
1.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.2K
01:30Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20