Design of Proanthocyanidins and TiO₂ Nanoparticles-Based Novel Emulsions as a Platform for UV Protection

A white oil-in-water novel emulsion stabilized by TiO₂ nanoparticles with UVB shielding properties and proanthocyanidins with antioxidant activity was prepared, where the proanthocyanidins aggregated at the oil-water interface to reduce interfacial tension while TiO₂ nanoparticles were dispersed in the continuous water phase to hinder droplet coalescence. It was found that the average oil droplet size was less than 10 μm and decreased with the increase of proanthocyanidins concentration, but the increase of the content of TiO₂ nanoparticles had little effect on it. The combination of TiO₂ nanoparticles and proanthocyanidins was versatile for oil phases with different polarities, and the resulting emulsion exhibited high stability in the face of centrifugation, heating and prolonging storage time. After encapsulating the UVA filter avobenzone in white oil, the emulsion was endowed with the ability to resist UVB and UVA. Further, the emulsion showed great free radical scavenging ability for superoxide anion radical (⋅O₂ ^- ), hydroxyl radical (⋅OH) with the clearance rate of over 70 %, indicating the good antioxidant activity. The ingenious combination of UVB, UVA filter and antioxidant with emulsion as carrier provides a new idea for the preparation of full-band sunscreen emulsion.