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Adenoma Detection Rate in Average-Risk Population: An Observational Consecutive Retrospective Study
Xiaoyan He1, Xiangyin Lv1, Binbin Zhang1
1Department of Gastroenterology, Dongyang Hospital affiliated to Wenzhou Medical University, Dongyang, China.
Cancer Control : Journal of the Moffitt Cancer Center
|August 2, 2023
Summary
Screening for colorectal cancer via colonoscopy shows increased adenoma detection rates in individuals aged 45 and older. This trend is particularly notable in men, suggesting an optimal age for initiating screening in average-risk populations.
Area of Science:
- Gastroenterology
- Oncology
- Preventive Medicine
Background:
- Colonoscopy is crucial for reducing colorectal cancer (CRC) morbidity.
- The optimal age for initiating CRC screening in average-risk individuals remains unclear.
- This study investigates adenoma and advanced adenoma detection rates based on age and sex in Eastern China.
Purpose of the Study:
- To compare adenoma and advanced adenoma detection rates across different age groups and sexes.
- To identify potential age thresholds for CRC screening initiation.
- To analyze the relationship between patient age, tumor size, and advanced adenoma presence.
Main Methods:
- Retrospective, observational, single-center study.
- Inclusion of 18,928 average-risk patients.
- Analysis of adenoma and advanced adenoma detection rates stratified by 5-year age intervals and sex.
Main Results:
- Overall adenoma and advanced adenoma detection rates were 17.08% and 5.24%, respectively.
- Detection rates for both adenoma and advanced adenoma increased significantly with age, particularly from age 45 onwards.
- Patients with advanced adenomas were older and had larger tumors compared to those without.
Conclusions:
- Adenoma and advanced adenoma detection rates significantly increase in average-risk individuals aged 45 and older.
- Men show a particularly pronounced increase in detection rates with age.
- Findings suggest that age 45 may be a critical point for initiating colonoscopic screening.
