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Expression and prognostic value of Cripto-1 in early non-small cell lung cancer
Jian Zhong1, Li Li2,3, Qian Zhang2,3
1Department of Thoracic Surgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Objective:
We aim to explore the expression of Cripto-1 (CR-1) protein in patients with early stage non-small cell lung cancer (NSCLC).
Methods:
We investigated CR-1 expression status in specimens obtained from 240 patients with resected NSCLC and 30 cases of para-carcinous normal lung tissues.
Results:
Compared with normal lung tissue, the positive expression of CR-1 protein in NSCLC was significantly increased (p < 0.005). Cox multivariate regression analysis showed that the expression of CR-1 protein was an independent prognostic factor for early stage NSCLC (p = 0.002).
Conclusion:
Detecting CR-1 protein can predict the prognosis and recurrence in patients with NSCLC.
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