Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148
Nursing Ethical Principles II01:27

Nursing Ethical Principles II

1.0K
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
1.0K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

2.8K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
2.8K
Ethical Dilemmas II01:30

Ethical Dilemmas II

1.1K
Resolving an ethical dilemma in healthcare involves a systematic approach that considers every aspect of the issue, respecting both the patient's needs and values and the healthcare professional's ethical obligations. Here are potential steps to resolve an ethical dilemma:
1.1K
Pharmacovigilance01:19

Pharmacovigilance

891
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
891
Ethical Issues01:27

Ethical Issues

1.0K
Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Filling the mechanistic and methodological gaps for predicting cytokine release syndrome in humans.

Frontiers in pharmacology·2026
Same author

Accelerating AOP Development in the AOP-Wiki with AI: A Practical Road Map for the Community.

Environmental science & technology·2026
Same author

Methods2AOP: A Collaboration to Strengthen the Integration of Test Methods into the Adverse Outcome Pathway Framework.

F1000Research·2026
Same author

Best Practices for the Development and Application of Bioinformatics Approaches for Species Extrapolation in Chemical Safety Assessment.

Integrated environmental assessment and management·2026
Same author

Atypical Ductular Reactions Are a Distinct Regenerative Phenomenon in Patients With Hepatocellular Carcinoma (HCC) After Transarterial Chemoembolization.

Laboratory investigation; a journal of technical methods and pathology·2026
Same author

Impact of chemical exposures on human infectious diseases: a scoping review to identify gaps and priorities.

International journal of hygiene and environmental health·2026
Same journal

New approach methodologies as first tier in an integrated approach to testing and assessment for non-genotoxic carcinogens.

ALTEX·2026
Same journal

Assessing the FDA's Year One Progress Report on Reducing Animal Testing.

ALTEX·2026
Same journal

Europe's roadmap finally arrives: Long on rigor, short on a clock.

ALTEX·2026
Same journal

Towards advanced in vitro models of testicular steroidogenesis for endocrine disruption testing.

ALTEX·2026
Same journal

Evaluation of EndoSens: A reliable skin sensitization assessment model.

ALTEX·2026
Same journal

Serum-free in vitro assessment of receptor-mediated endocrine activity including Phase-1 metabolism.

ALTEX·2026
See all related articles

Related Experiment Video

Updated: Jul 20, 2025

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

23.7K

Why adverse outcome pathways need to be FAIR.

Clemens Wittwehr1, Laure-Alix Clerbaux1, Stephen Edwards2

  • 1European Commission, Joint Research Centre (JRC), Ispra, Italy.

ALTEX
|August 2, 2023
PubMed
Summary
This summary is machine-generated.

Adverse outcome pathways (AOPs) are crucial for chemical risk assessment and reducing animal testing. Making AOPs machine-actionable using FAIR principles enhances their visibility, trust, and reusability for better scientific impact.

Keywords:
FAIR dataadverse outcome pathways (AOPs)machine-actionabilitytrustvisibility

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K

Related Experiment Videos

Last Updated: Jul 20, 2025

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

23.7K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K

Area of Science:

  • Toxicology and Risk Assessment
  • Computational Toxicology
  • Environmental Science

Background:

  • Adverse Outcome Pathways (AOPs) are gaining traction for assessing chemical risks and causality.
  • AOPs are essential for advancing chemical safety assessments and reducing reliance on animal testing.
  • The full potential of AOPs is limited by their lack of machine-actionability.

Purpose of the Study:

  • To highlight the necessity of machine-actionable Adverse Outcome Pathways (AOPs).
  • To explain how the FAIR principles (Findability, Accessibility, Interoperability, Reusability) support AOP machine-actionability.
  • To discuss the benefits of FAIRifying AOPs, including improved visibility and trustworthiness.

Main Methods:

  • Literature review and conceptual analysis of AOPs and FAIR principles.
  • Discussion of current challenges in AOP data utilization.
  • Elaboration on the application of FAIR data principles to AOP knowledge.

Main Results:

  • AOPs require machine-actionability to maximize their impact in risk assessment.
  • FAIR principles are fundamental for achieving AOP machine-actionability.
  • FAIRification of AOPs leads to enhanced data visibility and increased scientific trust.

Conclusions:

  • Adverse Outcome Pathways (AOPs) must be FAIR to be fully utilized.
  • Implementing FAIR principles in AOPs is key to advancing chemical risk assessment.
  • FAIR data practices will increase the reliability and accessibility of toxicological knowledge.