Related Experiment Video
Updated: Jul 20, 2025
14:55
Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
15.5K
[Assembly and Disassembly of the Nuclear Pore Complex: A View from the Structural Side]
A V Orlova1,2, S G Georgieva1, D V Kopytova1
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Molekuliarnaia Biologiia
|August 2, 2023
Summary
Nuclear pore complexes (NPCs) facilitate nucleocytoplasmic transport via nucleoporins. This study details NPC structure, properties, and cell cycle-dependent assembly/disassembly mechanisms.
Area of Science:
- Cell Biology
- Structural Biology
Context:
- Nucleocytoplasmic transport is essential for cellular function, mediated by nuclear pore complexes (NPCs).
- NPCs are intricate protein structures spanning the nuclear envelope, regulating molecular traffic.
- Understanding NPC architecture and dynamics is crucial for cell biology.
Purpose:
- To elucidate the structural organization and properties of nucleoporins within NPCs.
- To investigate the mechanisms governing NPC assembly and disassembly during the cell cycle.
Summary:
- This work examines the hierarchical organization of NPCs, built from nucleoporins forming octameric structures.
- It details the permeability barrier within NPCs enabling selective molecular transport.
- The study covers both the static structure and dynamic assembly/disassembly processes of NPCs.
Impact:
- Provides a comprehensive overview of nuclear pore complex structure and function.
- Offers insights into the dynamic regulation of nucleocytoplasmic transport.
- Contributes to understanding fundamental cellular processes and potential therapeutic targets.
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